Structure of PDB 8gap Chain H

Receptor sequence

>8gapH (length=384) Species: 5911 (Tetrahymena thermophila)

QFQDCMAHITELNFKRNYQNLTEQSSSNNVVAEELDIKESLKLQMEYYFC
DTNLTHDSYLRGIISKSPKNCVDIKVFLKFNKIQQILKSKKDLIHLIRDS
LKESKILKVKMDSLKVKRRFPFNLEQALKNSKQRTLYIDFLPPKCSKQTL
VSIFGNFRIININLPLQKNSQLCQGFAFIEFFSEEEANQALITKNSSIPK
ELILLTEKKIGQGSIRIITYKKWQEEKQSFKELSKNQNEQKNKNMNQSRK
ASDEFVSIDVEIKQNCLIKIINIPQGTLKAEVVLAVRHLGYEFYCDYIDE
NSNQLNDLLKEGQAMIRFQNSDEQRLAIQKLLNHNNNKLQIEIRGQICDV
ISTIPEDEEKNYWNYIKFKKNEFRKFFFMKKQQK

3D structure

• PDB: 8gap Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.
• Chain: H
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	N101 E104 Y128 Y129 H137 Y140 K147 S148 P149 K150 C152 K160 F161 N162 K163 K203 K221 K223 S226 K228 P234 K281 K348 R362 S365 D366 E374 I375 K392 R400 E405 F406 Y407 D409 R465 F466 Q467 I514 K518 F521 R522 F524 F525 K528	N20 E23 Y47 Y48 H56 Y59 K66 S67 P68 K69 C71 K79 F80 N81 K82 K90 K108 K110 S113 K115 P121 K168 K235 R249 S252 D253 E261 I262 K279 R287 E292 F293 Y294 D296 R317 F318 Q319 I366 K370 F373 R374 F376 F377 K380

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0070034 telomerase RNA binding

Biological Process

• GO:0007004 telomere maintenance via telomerase
• GO:0090669 telomerase RNA stabilization
• GO:1904868 telomerase catalytic core complex assembly

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0005694 chromosome
• GO:0005697 telomerase holoenzyme complex

External links

• PDB: RCSB:8gap, PDBe:8gap, PDBj:8gap
• PDBsum: 8gap
• PubMed: 37330293
• UniProt: W7X6T2|LARP7_TETTS La-related protein 7 homolog (Gene Name=TAP65)