Structure of PDB 8f6m Chain H

Receptor sequence
>8f6mH (length=522) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
SAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVE
TLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVA
VALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWL
DYKNICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGV
NLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILG
EKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLA
QKMIIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCI
MLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARASSHSTDLM
EAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQT
ARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVV
IVLTGWRPGSGFTNTMRVVPVP
3D structure
PDB8f6m PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes.
ChainH
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GZ3 H K269 E271 A292 R293 G294 D295 T327 K261 E263 A284 R285 G286 D287 T319
BS02 MN H E271 D295 E263 D287
BS03 ALA H N69 H463 I468 F469 N61 H455 I460 F461
BS04 MN H G294 D295 G286 D287
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003729 mRNA binding
GO:0003824 catalytic activity
GO:0004713 protein tyrosine kinase activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0006417 regulation of translation
GO:0016310 phosphorylation
GO:0032869 cellular response to insulin stimulus
GO:1903672 positive regulation of sprouting angiogenesis
GO:2000767 positive regulation of cytoplasmic translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f6m, PDBe:8f6m, PDBj:8f6m
PDBsum8f6m
PubMed37171062
UniProtP11974|KPYM_RABIT Pyruvate kinase PKM (Gene Name=PKM)

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