Structure of PDB 8crx Chain H

Receptor sequence
>8crxH (length=134) Species: 1747 (Cutibacterium acnes) [Search protein sequence]
TMTDPIADMLTRLRNANQAYHDQTSMPHSKIKAGIAGILKSEGYIADYKV
NEPKEGEVGKTLTLTLKYGENRERSIAGVRRISKPGLRVYAKSTALPKVL
GGLGIAIISTSQGLLTDKQAHEKSVGGEVLAYVW
3D structure
PDB8crx Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
ChainH
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna H T2 T4 P6 D9 T12 R13 R15 N16 Q19 H22 S30 K31 V59 K85 P86 G87 R89 Y91 K93 S94 K99 S110 T111 S112 K119 H122 S125 G127 E129 T1 T3 P5 D8 T11 R12 R14 N15 Q18 H21 S29 K30 V58 K84 P85 G86 R88 Y90 K92 S93 K98 S109 T110 S111 K118 H121 S124 G126 E128
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8crx, PDBe:8crx, PDBj:8crx
PDBsum8crx
PubMed36864821
UniProtA0A2B7ITQ7

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