Structure of PDB 8btp Chain H

Receptor sequence
>8btpH (length=473) Species: 1053222 (Bacillus cereus MSX-D12) [Search protein sequence]
KMNPIVELFIKDFTKEVMEENAAIFAGAGLSMSVGYVSWAKLLEPIAQEI
GLDVNKENDLVSLAQYYCNENQGNRGRINQIILDEFSRKVDLTENHKILA
RLPIHTYWTTAYDRLIEKALEEENKIADVKYTVKQLATTKVKRDAVVYKM
HGDVEHPSEAVLIKDDYEKYSIKMDPYIKALSGDLVSKTFLFVGFSFTDP
NLDYILSRVRSAYERDQRRHYCLIKKEERRPDELEADFEYRVRKQELFIS
DLSRFNIKTIVLNNYNEITEILQRIENNIKTKTVFLSGSAVEYNHWETEH
AEQFIHQLSKELIRKDFNIVSGFGLGVGSFVINGVLEELYMGTIDDDRLI
LRPFPQGKKGEEQWDKYRRDMITRTGVSIFLYGNKIDKGQVVKAKGVQSE
FNISFEQNNYVVPVGATGYIAKDLWNKVNEEFETYYPGADARMKKLFGEL
NNEALSIEELINTIIEFVEILSN
3D structure
PDB8btp Activation of Thoeris antiviral system via SIR2 effector filament assembly
ChainH
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.5: NAD(+) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RK3 H G289 S290 G325 L326 F357 W367 K388 A397 G399 V400 E403 G288 S289 G324 L325 F354 W364 K385 A394 G396 V397 E400
BS02 ENA H G28 A29 G30 S34 G195 S197 Y266 G27 A28 G29 S33 G194 S196 Y265
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016787 hydrolase activity
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8btp, PDBe:8btp, PDBj:8btp
PDBsum8btp
PubMed38383786
UniProtJ8G6Z1|THSA_BACCS NAD(+) hydrolase ThsA (Gene Name=thsA)

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