Structure of PDB 8axv Chain H

Receptor sequence
>8axvH (length=429) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
PVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLIE
QEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLAS
AAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQD
VYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWADE
QVLKAKNIGLCSTDLTEGRGKKLEPCDRVLFSVGSTLYPESRKLLKSWHL
PSVFHLKGKLSFTCRCDTVVSCEGYVVKRITMSPGLYGKTTGYAVTHHAD
GFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTPEDAQKLLV
GLNQTNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVREFKKQKTHTV
YKRPDTQSIQKVQAEFDSGLSIPLRTRIK
3D structure
PDB8axv Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.
ChainH
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN H H79 C134 Q143 H77 C132 Q141
BS02 MY6 H D152 Y154 F241 Y248 E250 D150 Y152 F231 Y238 E240
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

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Molecular Function
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Biological Process
External links
PDB RCSB:8axv, PDBe:8axv, PDBj:8axv
PDBsum8axv
PubMed36913573
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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