Structure of PDB 8ase Chain H

Receptor sequence

>8aseH (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHYERNIEKISMLEKIYIHPRYNWRENLDRDIALMK
LKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGK
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQF

3D structure

PDB

8ase Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3

Chain

Resolution

2.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 M26 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207	E8 M11 W14 D109 H112 P113 C115 Y130 K131 R133 N160 M207 K208 P210 N213 R214 W215
BS02	NWR	H	Y60A W60D N98 L99 A190 C191 E192 V213 W215 G216 F227	Y47 W50 N91 L92 A196 C197 E198 V221 W223 G224 F235

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8ase, PDBe:8ase, PDBj:8ase
PDBsum	8ase
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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