Structure of PDB 7zko Chain H

Receptor sequence

>7zkoH (length=249) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF

3D structure

• PDB: 7zko A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
• Chain: H
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 I24 G25 M26 D116 H119 P120 V121 C122 L129C Y134 K135 R137 N159 K202 P204 R206 W207	E8 I9 G10 M11 D113 H116 P117 V118 C119 L129 Y134 K135 R137 N156 K204 P206 R210 W211
BS02	dna	H	I24 R75 Y76 E77 R77A I79 Y117	I9 R70 Y71 E72 R73 I75 Y114
BS03	dna	H	Y89 I90 P92 R93 Y94 W96 R97 W237 K240 Q244	Y85 I86 P88 R89 Y90 W92 R93 W241 K244 Q248
BS04	0G6	H	H57 Y60A W60D L99 D189 A190 C191 G193 S195 S214 W215 G216	H43 Y47 W50 L96 D191 A192 C193 G195 S197 S218 W219 G220

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:7zko, PDBe:7zko, PDBj:7zko
• PDBsum: 7zko
• PubMed: 36457701
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)