Structure of PDB 7zkm Chain H

Receptor sequence

>7zkmH (length=250) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

3D structure

• PDB: 7zkm A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
• Chain: H
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 I24 G25 M26 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207	E8 I9 G10 M11 W14 D113 H116 P117 C119 Y134 K135 R137 N155 K203 P205 N208 R209 W210
BS02	dna	H	I24 R75 Y76 E77 R77A N78 I79 Y117	I9 R70 Y71 E72 R73 N74 I75 Y114
BS03	dna	H	Y89 P92 R93 N95 W96 R97 W237 K240 Q244	Y85 P88 R89 N91 W92 R93 W240 K243 Q247
BS04	0G6	H	H57 Y60A W60D L99 D189 A190 S195 S214 W215 G216	H43 Y47 W50 L96 D190 A191 S196 S217 W218 G219

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:7zkm, PDBe:7zkm, PDBj:7zkm
• PDBsum: 7zkm
• PubMed: 36457701
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)