Structure of PDB 7zkl Chain H

Receptor sequence
>7zklH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
3D structure
PDB7zkl A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
ChainH
Resolution3.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna H I24 R75 Y76 E77 R77A N78 I79 Y117 I9 R70 Y71 E72 R73 N74 I75 Y114
BS02 0G6 H H57 Y60A W60D N98 L99 D189 A190 C191 G193 S195 S214 W215 G216 H43 Y47 W50 N95 L96 D193 A194 C195 G197 S199 S220 W221 G222
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:7zkl, PDBe:7zkl, PDBj:7zkl
PDBsum7zkl
PubMed36457701
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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