Structure of PDB 7z5n Chain H

Receptor sequence
>7z5nH (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEW
VAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHL
CLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSII
HCDLKPENILLCNPKRSAIKIVDFGSSCQLGQYIQSRFYRSPEVLMPYDL
AIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPREYKPPGTR
KLHNILGVETGGPGGRRASGHTVADYLKFKDLILRMLDYDPKTRIQPYYA
LQHSFFK
3D structure
PDB7z5n Crystal structure DYRK1A in complex with CX-4945
ChainH
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.23: [RNA-polymerase]-subunit kinase.
2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3NG H V180 Q182 V46 Q48
BS02 3NG H I165 G166 K167 V173 K188 V222 F238 E239 M240 L241 V306 D307 I31 G32 K33 V39 K54 V88 F104 E105 M106 L107 V172 D173
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0046777 protein autophosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7z5n, PDBe:7z5n, PDBj:7z5n
PDBsum7z5n
PubMed
UniProtQ13627|DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Gene Name=DYRK1A)

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