Structure of PDB 7yxd Chain H

Receptor sequence
>7yxdH (length=241) Species: 32644 (unidentified) [Search protein sequence]
FPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKRNWQRFYQLTKLLDSMHEMVGGLLQ
FCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFH
3D structure
PDB7yxd The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
ChainH
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H V575 K579 M593 E751 M752 E755 V47 K51 M65 E217 M218 E221
BS02 DEX H L563 N564 Q570 M601 M604 F623 Q642 C736 T739 L35 N36 Q42 M73 M76 F95 Q114 C202 T205
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxd, PDBe:7yxd, PDBj:7yxd
PDBsum7yxd
PubMed36464162
UniProtA0A1X8XLE9

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