Structure of PDB 7xxc Chain H

Receptor sequence

>7xxcH (length=479) Species: 285500 (Streptomyces luteocolor)

VIVVGNGVLGLSVGVEIARTRPDVRVTLLGKPARQYGATPAAGAMLGAFG
EVTAHALASEHGRKKHALAVQAQRLWPEWIESLEATGTAADGRIKTADDT
VVLLNTVGHSALDDANFAAVLTALKEANAPHEEIAVESVDWIDPDPNSRP
LRALHIEGEGSVDSGILLAALERSFLQAGGRLHPVDATEIRASHGRVEGV
VTDDGDFLPAGHVVVAAGARSQRLVAALPGLAHRIPRIYDGVGVSALVDT
WDGSGPATVLRTSNRAFACGLHLVPRAGGSVYIGATNAVCLEPRGAASIE
ETVFLFNCATHQLHRGLNGSELRKVQVGSRPAPIDGFPLIGGTSVEGLWM
LSGTYRDGLHMSPLLARHVVSLMDGGTGVDGLREFRPERDLISAWSREEI
LDDVVRHTMATGYEFPWRLPLEWPHMMETFLQGPFAELADRLSDTYTPPA
DLMTAIMFSEREQQDELIAYYADVHREWH

3D structure

• PDB: 7xxc N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
• Chain: H
• Resolution: 1.989 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	H	N18 G19 L21 G42 R46 Q47 G49 A50 T51 A53 A54 A56 M57 D198 A199 A229 G230 R232 G340 R342 P343 T366 Y367 R368 D369 G370 L371 H372	N6 G7 L9 G30 R34 Q35 G37 A38 T39 A41 A42 A44 M45 D186 A187 A217 G218 R220 G328 R330 P331 T354 Y355 R356 D357 G358 L359 H360
BS02	I55	H	N299 S310 E312 T423 T466 F470	N287 S298 E300 T411 T454 F458
BS03	GLY	H	R342 R368	R330 R356

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7xxc, PDBe:7xxc, PDBj:7xxc
• PDBsum: 7xxc
• PubMed: 37137912
• UniProt: A0A125SZC1