Structure of PDB 7uac Chain H

Receptor sequence
>7uacH (length=546) Species: 9606 (Homo sapiens) [Search protein sequence]
ADFGEQKDISEINLAAGLDLFQGDILLQNTRWTFPIPYILADNLGLNAKG
AILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISI
GQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDT
YTDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAI
DLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAG
EVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFY
KMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEE
QKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENT
SKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILE
WPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSVIWDRPSRVGTYH
TDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLS
3D structure
PDB7uac Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
ChainH
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.18: meprin A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC H T351 G352 N414 T416 T303 G304 N366 T368
BS02 CA H G282 D285 T287 D288 G234 D237 T239 D240
BS03 ZN H D58 H155 H159 H165 D24 H112 H116 H122
BS04 CA H T270 E272 D301 T303 Y313 D422 T222 E224 D253 T255 Y265 D374
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uac, PDBe:7uac, PDBj:7uac
PDBsum7uac
PubMed36261433
UniProtQ16819|MEP1A_HUMAN Meprin A subunit alpha (Gene Name=MEP1A)

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