Structure of PDB 7syx Chain H

Receptor sequence

>7syxH (length=237) Species: 9986 (Oryctolagus cuniculus)

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL

3D structure

• PDB: 7syx Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Chain: H
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	K2 S6 P8 Q13 R31 S53 K58 Q59 G60 G66 R72 R74 C83 R85 R87 R88 G90 E91 R92 K93 R94 K95 S107 V108 N110 V112 L133 G134 K136 R137 S139 R140 R154 R159 K160 L162 K164 K167 R170 P174 K175 Q177 R178 R183 Q186 H187 K188 R189 R190 R191 K195 K196 R198 K201 L237	K2 S6 P8 Q13 R31 S53 K58 Q59 G60 G66 R72 R74 C83 R85 R87 R88 G90 E91 R92 K93 R94 K95 S107 V108 N110 V112 L133 G134 K136 R137 S139 R140 R154 R159 K160 L162 K164 K167 R170 P174 K175 Q177 R178 R183 Q186 H187 K188 R189 R190 R191 K195 K196 R198 K201 L237

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7syx, PDBe:7syx, PDBj:7syx
• PDBsum: 7syx
• PubMed: 35822879
• UniProt: A0A5K1UJS7