Structure of PDB 7syp Chain H

Receptor sequence

>7sypH (length=237) Species: 9986 (Oryctolagus cuniculus)

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL

3D structure

• PDB: 7syp Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Chain: H
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	K2 N4 S6 P8 Q13 L15 R31 S53 N56 Q59 G60 Q65 G66 R74 L75 C83 Y84 R85 R87 R88 G90 R92 R94 S96 V108 N110 R131 R132 L133 G134 K136 R137 S139 R140 R154 Q155 R159 K160 L162 K164 K167 R170 K172 A173 P174 K175 I176 R178 L179 R183 Q186 H187 R189 R190 R191 K195 K196 R198 T199 K201 N202 L237	K2 N4 S6 P8 Q13 L15 R31 S53 N56 Q59 G60 Q65 G66 R74 L75 C83 Y84 R85 R87 R88 G90 R92 R94 S96 V108 N110 R131 R132 L133 G134 K136 R137 S139 R140 R154 Q155 R159 K160 L162 K164 K167 R170 K172 A173 P174 K175 I176 R178 L179 R183 Q186 H187 R189 R190 R191 K195 K196 R198 T199 K201 N202 L237

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7syp, PDBe:7syp, PDBj:7syp
• PDBsum: 7syp
• PubMed: 35822879
• UniProt: A0A5K1UJS7