Structure of PDB 7rfe Chain H

Receptor sequence

>7rfeH (length=475) Species: 9606 (Homo sapiens) [Search protein sequence]

GYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKF
EQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTS
RDIVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIAR
TDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLD
SSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVG
MGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVV
KALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMKVKI
AQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELK
FEKRTMSAQIEGGVHGLHSYEKRLY

3D structure

PDB

7rfe IMPDH1 retinal variants control filament architecture to tune allosteric regulation.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	H	E111 Q112 N198 N230 K238 K242	E101 Q102 N174 N206 K214 K218
BS02	GTP	H	K109 Q112 I115 P118 K134 F139 S140 G141 K208 T225 D226 K229	K99 Q102 I105 P108 K124 F129 S130 G131 K184 T201 D202 K205
BS03	ATP	H	T159 R161 D162 T180 L185 V186 K206 G207 K208	T149 R151 D152 T156 L161 V162 K182 G183 K184
BS04	IMP	H	S68 M70 G328 S329 I330 C331 D364 G365 G366 G387 S388 Y411 G413 M414 G415 Q441 G442	S58 M60 G304 S305 I306 C307 D340 G341 G342 G363 S364 Y387 G389 M390 G391 Q402 G403

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7rfe, PDBe:7rfe, PDBj:7rfe
PDBsum	7rfe
PubMed	35013599
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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