Structure of PDB 7r4g Chain H

Receptor sequence
>7r4gH (length=313) Species: 9913 (Bos taurus) [Search protein sequence]
MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIA
DAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNL
GVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIIL
LSVLLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDL
TEGESELVSGFAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELY
TINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHV
SLPILTSGIPPQT
3D structure
PDB7r4g Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
ChainH
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I49 H A18 P48 L55 F224 M225 A18 P48 L55 F219 M220
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0009060 aerobic respiration
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045271 respiratory chain complex I

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Cellular Component
External links
PDB RCSB:7r4g, PDBe:7r4g, PDBj:7r4g
PDBsum7r4g
PubMed36701435
UniProtP03887|NU1M_BOVIN NADH-ubiquinone oxidoreductase chain 1 (Gene Name=MT-ND1)

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