Structure of PDB 7pzy Chain H

Receptor sequence

>7pzyH (length=226) Species: 237561 (Candida albicans SC5314)

MKLNISYPANGTQKSIDIDDEHKLRVFYEKRMGQEVEGDSVGDEFKGYIF
KITGGNDKQGFPMKQGVMHPTRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVAQDLSVLALSIVKQGDNEIEGLTDTTVPKRLGPKRANHIRKFFGLTKE
DDVRDFVVRREVTKGDKTYTKAPKIQRLVTPQTLQRKRALKAKKVKNAQQ
QRDAAAEYAQLLAKRLHERKEERAEI

3D structure

• PDB: 7pzy E-site drug specificity of the human pathogen Candida albicans ribosome.
• Chain: H
• Resolution: 2.32 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	K2 N4 S6 P8 Q13 S15 R31 T53 N56 K58 Q59 G60 F61 P62 Q65 G66 M68 R72 L76 H81 C83 Y84 R85 R87 R88 T89 G90 R92 R94 K95 S96 A110 K131 R132 L133 G134 P135 K136 R137 N139 H140 K149 R154 R159 R160 K164 K167 Y169 K171 A172 P173 K174 I175 Q176 R177 L178 V179 T183 L184 Q185 R186 K187 R188 L190 K191 K194 V195 N197 A198 Q201 R202 K220	K2 N4 S6 P8 Q13 S15 R31 T53 N56 K58 Q59 G60 F61 P62 Q65 G66 M68 R72 L76 H81 C83 Y84 R85 R87 R88 T89 G90 R92 R94 K95 S96 A110 K131 R132 L133 G134 P135 K136 R137 N139 H140 K149 R154 R159 R160 K164 K167 Y169 K171 A172 P173 K174 I175 Q176 R177 L178 V179 T183 L184 Q185 R186 K187 R188 L190 K191 K194 V195 N197 A198 Q201 R202 K220

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0009986 cell surface
• GO:0030445 yeast-form cell wall
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pzy, PDBe:7pzy, PDBj:7pzy
• PDBsum: 7pzy
• PubMed: 35613268
• UniProt: A0A1D8PL99|RS6A_CANAL Small ribosomal subunit protein eS6 (Gene Name=RPS6A)