Structure of PDB 7oni Chain H

Receptor sequence
>7oniH (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
IEDYYVGVASDVEQQGFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVS
HSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPSHPPHHCAVCM
QFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTP
EDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPR
ARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADNQSQQAQAREA
LKKYLFYFERWENHNKSLQAAAQTYQRIHEKIQERVMNNLGTWIDWQYLQ
NAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIANLSWKV
ERADSYDRGDLENQMHIAEQRRRTLLKDFH
3D structure
PDB7oni CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
ChainH
Resolution3.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN H C257 H265 C270 C214 H222 C227
BS02 ZN H C139 C142 C161 C164 C96 C99 C118 C121
BS03 ZN H C233 C249 C252 C190 C206 C209
BS04 ZN H C156 H158 C183 C188 C113 H115 C140 C145
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048588 developmental cell growth
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071425 hematopoietic stem cell proliferation
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031466 Cul5-RING ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oni, PDBe:7oni, PDBj:7oni
PDBsum7oni
PubMed34518685
UniProtO95376|ARI2_HUMAN E3 ubiquitin-protein ligase ARIH2 (Gene Name=ARIH2)

[Back to BioLiP]