Structure of PDB 7md6 Chain H

Receptor sequence
>7md6H (length=380) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
SNKKTKLIHGGHTTDDYTGAVTTPIYQTSTYLQDDIGDLRQGYEYSRTAN
PTRSSVESVIATLENGKHGFAFSSGVAAISAVVMLLDKGDHIILNSDVYG
GTNRALTKVFTRFGIEVDFVDTTHTDSIVQAIRPTTKMLFIETPSNPLLR
VTDIKKSAEIAKEHGLISVVDNTFMTPYYQNPLDLGIDIVLHSATKYLGG
HSDVVAGLVATSDDKLAERLAFISNSTGGILGPQDSYLLVRGIKTLGLRM
EQINRSVIEIIKMLQAHPAVQQVFHPSIESHLNHDVHMAQADGHTGVIAF
EVKNTESAKQLIKATSYYTLAESLGAVESLISVPALMTHASIPADIRAKE
GITDGLVRISVGIEDTEDLVDDLKQALDTL
3D structure
PDB7md6 Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance.
ChainH
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.48: cystathionine gamma-synthase.
4.4.1.1: cystathionine gamma-lyase.
4.4.1.8: Transferred entry: 4.4.1.13.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LB6 H N103 T338 I342 E350 N103 T338 I342 E350
BS02 LB6 H S1 K6 S1 K6
BS03 LB6 H H12 Q41 Y43 P51 S54 H12 Q41 Y43 P51 S54
BS04 LB6 H L7 P177 Y178 L7 P177 Y178
BS05 LB6 H R219 F222 R219 F222
BS06 LB6 H L166 I167 D213 L216 R219 L166 I167 D213 L216 R219
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003962 cystathionine gamma-synthase activity
GO:0016846 carbon-sulfur lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7md6, PDBe:7md6, PDBj:7md6
PDBsum7md6
PubMed34112687
UniProtA0A0H3K724

[Back to BioLiP]