Structure of PDB 7lu5 Chain H

Receptor sequence
>7lu5H (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTHNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN
3D structure
PDB7lu5 Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
ChainH
Resolution3.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT H Y155 V156 V378 R451 K455 Y43 V44 V260 R333 K337
BS02 DGT H K116 I118 D137 Q142 K4 I6 D25 Q30
BS03 DGT H V156 F157 R372 H376 K377 V44 F45 R254 H258 K259
BS04 DGT H V117 N119 H125 V5 N7 H13
BS05 DGT H R333 K354 K523 R215 K236 K405
External links
PDB RCSB:7lu5, PDBe:7lu5, PDBj:7lu5
PDBsum7lu5
PubMed34492268
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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