Structure of PDB 7jxh Chain H

Receptor sequence
>7jxhH (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
PNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR
PKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHV
RENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVK
ITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV
TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVSEFSRMARDPQRFVVIQNE
3D structure
PDB7jxh A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.
ChainH
Resolution3.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VOY H L726 A751 K753 M774 S783 T798 L800 M801 G804 C805 L852 T862 D863 F864 L20 A45 K47 M64 S73 T88 L90 M91 G94 C95 L142 T152 D153 F154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxh, PDBe:7jxh, PDBj:7jxh
PDBsum7jxh
PubMed35149586
UniProtP04626|ERBB2_HUMAN Receptor tyrosine-protein kinase erbB-2 (Gene Name=ERBB2)

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