Structure of PDB 7jov Chain H

Receptor sequence
>7jovH (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNR
YEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLS
KFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPG
GDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDK
HGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKDGFYGRECDWW
SVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL
ICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSD
IDSSNFDDIEDDVETFPIPKAFVGNQLPFIGFTYYR
3D structure
PDB7jov Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
ChainH
Resolution2.586 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D214 K216 N219 D232 T253
Catalytic site (residue number reindexed from 1) D190 K192 N195 D208 T229
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VFS H I98 G101 G104 E105 V106 A119 K121 M169 E170 Y171 M172 L221 A231 D232 I74 G77 G80 E81 V82 A95 K97 M145 E146 Y147 M148 L197 A207 D208 BindingDB: IC50=2.90nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jov, PDBe:7jov, PDBj:7jov
PDBsum7jov
PubMed32798651
UniProtO75116|ROCK2_HUMAN Rho-associated protein kinase 2 (Gene Name=ROCK2)

[Back to BioLiP]