Structure of PDB 7ekk Chain H

Receptor sequence

>7ekkH (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]

VQLVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGGV
IPLLTITNYAPRFQGRITITADRSTSTAYLELNSLRPEDTAVYYCAREGT
TGCGGKPIGAFAHWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDY
FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEP

3D structure

PDB

7ekk Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.

Chain

Resolution

1.7 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	T31 W47 G50 V51 I52 I56 N58 E95 G100D K100E P100F	T30 W46 G49 V50 I51 I56 N58 E98 G105 K106 P107

External links

PDB	RCSB:7ekk, PDBe:7ekk, PDBj:7ekk
PDBsum	7ekk
PubMed	34505005

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