Structure of PDB 7ekb Chain H

Receptor sequence

>7ekbH (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]

QVQLVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGG
VIPLLTITNYAPRFQGRITITADRSTSTAYLELNSLRPEDTAVYYCAREG
TTGKPIGAFAHWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFP
EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN
VNHKPSNTKVDKKVEP

3D structure

PDB

7ekb Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.

Chain

Resolution

1.45 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	T31 G50 V51 I52 L53 L54 I56 N58 E95 G100D K100E P100F	T31 G50 V51 I52 L54 L55 I57 N59 E99 G103 K104 P105

External links

PDB	RCSB:7ekb, PDBe:7ekb, PDBj:7ekb
PDBsum	7ekb
PubMed	34505005

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