Structure of PDB 7dy2 Chain H

Receptor sequence

>7dy2H (length=460) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

IAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEF
DEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDDLSALI
ERINYAIQKYRARRVSIDSVTSVFQVVRRELFRLVARLKQIGATTVMTTE
RIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRGTSHMKG
EYPFTITDHGINIFPLQRSSNVRVSSGVVRLDEMCGGGFFKDSIILATGA
TGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGMDFEEME
RQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSALARGVSN
NAFRQFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHISTITDTIIL
LQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSFRNFERI
ISGSPTRITV

3D structure

PDB

7dy2 Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.

Chain

Resolution

3.04 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	H	K224 L225 T228 S229 H230 K232	K191 L192 T195 S196 H197 K199
BS02	ATP	H	K457 R459 G460 S461 W462 H463	K418 R420 G421 S422 W423 H424
BS03	ADP	H	T50 G51 K52 T53 L54 S89 F90 R218 I239	T33 G34 K35 T36 L37 S72 F73 R185 I206
BS04	ATP	H	T290 G291 T292 G293 K294 T295 L296 W331 R451 I472	T251 G252 T253 G254 K255 T256 L257 W292 R412 I433
BS05	MG	H	T295 D378	T256 D339

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7dy2, PDBe:7dy2, PDBj:7dy2
PDBsum	7dy2
PubMed	35427168
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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