Structure of PDB 7bkc Chain H

Receptor sequence

>7bkcH (length=438) Species: 323259 (Methanospirillum hungatei JF-1)

PKVIENVGCPYCGCSCDDVRITVSDDGKDILEVENVCAIGTEIFKHGCSK
DRIRLPRMRQPDGSMKDISYEEAIDWTARHLLKAKKPLMYGFGSTNCEGQ
AAAARVMEIAGGMLDNCATICHGPSFLAIFDNGYPSCTLGEVKNRADVIV
YWGSNPAHAHPRHMSRYSIFPRGFFTGKGQKKRTVIVIDPRFTDTANVAD
YHLQVKQGHDYELFNAFRMVIHGHGKDLPDEVAGIKKETILEVAEIMKNA
RFGTTFFGMGLTHTDGRNHNIDIAISLTRDLNKISKWTIMAMRGHYNIAG
PGVVWSWTFGFPYCLDLTKQNHAHMNPGETSSVDMAMRDEVDMFINIGTD
AAAHFPIPAVKQLKKHPWVTIDPSINMASEISDLHIPVCICGVDVGGIVY
RMDNVPIQFRKVIEPPEGVMDDETLLNKIADRMEELKA

3D structure

• PDB: 7bkc Three-megadalton complex of methanogenic electron-bifurcating and CO 2 -fixing enzymes.
• Chain: H
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 1.2.7.12: formylmethanofuran dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MGD	H	Y12 G154 N156 H159 A160 I189 D190 P191 R192 Q208 D211 M260 G261 G295 H296	Y11 G153 N155 H158 A159 I188 D189 P190 R191 Q207 D210 M259 G260 G294 H295
BS02	MGD	H	S95 I121 C122 H264 H296 G349 T350 D351 H355 P374 V389 C392	S94 I120 C121 H263 H295 G348 T349 D350 H354 P373 V388 C391
BS03	SF4	H	C10 C13 C15 C17 C38 R163	C9 C12 C14 C16 C37 R162

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0018493 formylmethanofuran dehydrogenase activity

Biological Process

• GO:0015948 methanogenesis
• GO:0019386 methanogenesis, from carbon dioxide

External links

• PDB: RCSB:7bkc, PDBe:7bkc, PDBj:7bkc
• PDBsum: 7bkc
• PubMed: 34516836
• UniProt: Q2FRM0