Structure of PDB 7b5m Chain H

Receptor sequence
>7b5mH (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
KCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQ
NCKAEFCWVCLGPWEPHGSAWYNCNAQERSRAALQRYLFYCNRYMNHMQS
LRAAHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYV
FAFYLKKNNQSIIFENNQADLENATAVLSGYLERDISDSLQDIKQKVQDK
YRYCESRRRVLLQHVHEGYEKDLWEY
3D structure
PDB7b5m Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
ChainH
Resolution3.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN H C344 C347 C362 C367 C29 C32 C47 C52
BS02 ZN H C375 H382 C60 H67
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0039585 PKR/eIFalpha signaling
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016604 nuclear body
GO:0019005 SCF ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0097413 Lewy body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b5m, PDBe:7b5m, PDBj:7b5m
PDBsum7b5m
PubMed33536622
UniProtQ9Y4X5|ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (Gene Name=ARIH1)

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