Structure of PDB 7alb Chain H

Receptor sequence
>7albH (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
PRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTK
GYQETISDVLNDAIFDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPN
KQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEAT
HMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIR
3D structure
PDB7alb A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
ChainH
Resolution1.979 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN H C141 H144 C212 C82 H85 C153
BS02 QBQ H F122 G164 L165 S166 K167 R170 F65 G105 L106 S107 K108 R111
BS03 QBQ H C141 H143 H144 V181 E183 R216 C82 H84 H85 V122 E124 R157
Gene Ontology
Molecular Function
GO:0003934 GTP cyclohydrolase I activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7alb, PDBe:7alb, PDBj:7alb
PDBsum7alb
PubMed33229582
UniProtP30793|GCH1_HUMAN GTP cyclohydrolase 1 (Gene Name=GCH1)

[Back to BioLiP]