Structure of PDB 6zgo Chain H

Receptor sequence

>6zgoH (length=259) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE

3D structure

• PDB: 6zgo Thrombin in complex with D-Phe-Pro-2-chlorofuran derivative (13l)
• Chain: H
• Resolution: 1.79 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D102 E192 G193 D194 S195 G196
• Catalytic site (residue number reindexed from 1): H43 D99 E202 G203 D204 S205 G206
• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 M211 K212 P214 N217 R218 W219
BS02	peptide	H	F34 T74 R75 Y76 K81 I82	F19 T69 R70 Y71 K77 I78
BS03	QKE	H	H57 Y60A W60D N98 L99 S195 V213 S214 W215 G216 F227	H43 Y47 W50 N95 L96 S205 V225 S226 W227 G228 F239

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:6zgo, PDBe:6zgo, PDBj:6zgo
• PDBsum: 6zgo
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)