Structure of PDB 6x32 Chain H

Receptor sequence

>6x32H (length=3798) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANTVEAGHRTLLYGHAILLRHAHSGMYLS
CLTTSRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDL
ILVSVSSERYLHLSTLQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLF
HGHMDECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSH
LRWGQPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKL
KRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDA
LSLTRCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALP
LEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLV
LNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANC
ALFSNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSII
SLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNL
INYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWA
LTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHL
LAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGV
KVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGP
HLVGPSRCLSHTDFVPCPLPPHLERIREKLAENIHELWALTRIEQGWTYG
PVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADE
KAEDNLRKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHN
VWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVR
TLLGYGYNIERVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELR
PDVELGADELAYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTI
IFTLNGEVLMSDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSS
LRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRV
DGTVDTPPCLRLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQE
PSCVWVGWVTPDYHQHDMNFDLTKVRAVTVTMGDNIHSSLKCSNCYMVWG
GDFVSHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVL
PTHQNVIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSW
SRMPNHFLRVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSE
RLDLQQFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPG
PLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPRRHGL
PGVGVTTSLRPPHHFSAPCFVAALPEAPARLSPSIPLEALRDKALRMLGE
AVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIE
PEVEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKL
QANQRDRYGILMKAFTMTAAETARRTREFRSPPQEQINMLLHFKPLPDEI
RQDLLEFHQDLLTHCGIQLQSLQELVSHTVVRWAQEDFVQSPELVRAMFS
LLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGP
QEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGKEIRFP
KMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVA
AASVIDNNELALALQEQDLEKVVSYLAGCGLQSYPDIGWNPCGGERYLDF
LRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLATIEEAI
RISEHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVP
LDDLVGIISLPKMSASFVPDHKASMVLFLDRVYGIENAAFLLHVLDVGFL
PDMRAAATFSTTEMALALNRYLCLAVLPLITKCAPLFAMVDSMLHTVYRL
SRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPRPVETLNV
IIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYK
TFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLSR
ELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARD
REKAQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPLLIRYVDNNRAHW
LTEPNPSAEELFRMVGEIFIYWSKAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARRAVVACFRM
TPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEE
EVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLSFE
EKEMEKQRLLYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISI
LNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAE
GLGMVNEDGTVEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNT
TTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQ
VFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQI
ELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILK
FFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAAAAAAEFANRFQEP
ARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMG
ASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFV
SFCEDTIFEMQIAAQIAAAAAAAAAAAAAAAAAEVQRVKFLNYLSRNFYT
LRFLALFLAFAINFILLFYKVSDSPPVYYFLEESTGYMEPALRCLSLLHT
LVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQW
DRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAEIDVKYQIWKFGV
IFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTH
NGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKDMKCDDMMTCYLFHMYV
GVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA
FGELRDQQEQVREDMETKCFICGIGSDYFDTTPHRFETHTLEEHNLANYM
FFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS

3D structure

• PDB: 6x32 Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
• Chain: H
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	H	C4956 H4976 H4981	C3719 H3739 H3744

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 18:25:16 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6x32', asym_id = 'H', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6x32', asym_id='H', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6x32', asym_id = 'H'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6x32', asym_id='H')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>