Structure of PDB 6waa Chain H

Receptor sequence

>6waaH (length=656) Species: 507522 (Klebsiella pneumoniae 342)

PALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKI
LNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSD
GLHIATLLCALFVRHFRTLVKEGHVYVALPPLYRIYYALRFKGLGEMNPM
QLRETTLDPNTRRLVQLVISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEK
GDMERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSEL
GLNASAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDG
QGNWGAPDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQ
EPKMLPARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTT
LDELLDIVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVWVITALPH
QVSGAKVLEQIAAQMRNKKLPMVSDHENPTRLMEQVMNHLFATTDLEKSY
RINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVLKRLHI
LEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILELKLRHL
AKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADADAFGDD
RRSPLH

3D structure

• PDB: 6waa Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
• Chain: H
• Resolution: 3.2 Å

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	H	K444 L446 N447 S459 H498 S613 Y1018 Y1120 I1172 A1173 G1175 M1176 S1324 R1326	K49 L51 N52 S64 H103 S190 Y216 Y318 I370 A371 G373 M374 S499 R501
BS02	dna	H	E419 G443 K444 D495 R1029 V1041 H1075 H1077 G1078 L1088	E24 G48 K49 D100 R227 V239 H273 H275 G276 L286
BS03	MG	H	D491 D493	D96 D98
BS04	TNJ	H	K442 E461 S1080	K47 E66 S278

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006265 DNA topological change

Cellular Component

• GO:0005694 chromosome

External links

• PDB: RCSB:6waa, PDBe:6waa, PDBj:6waa
• PDBsum: 6waa
• PubMed: 32634310
• UniProt: B5XU60