Structure of PDB 6w1n Chain H

Receptor sequence

>6w1nH (length=3719) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
LAICCFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHAHSGMYLSCLTT
SRSMTDKLAFDVGLQEDATGEACWWTTHPASKQRSEGEKVRVGDDLILVS
VSSERYLHLSTLQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFHGHM
DECLTISPADSDDQRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRWG
QPLRIRHVTTGRYLALIEDQGLVVVDASKAHTKATSFCFRISKEKLKRDV
EGMGPPEIKYGESLCFVQHVASGLWLTYAALKKKAILHQEGHMDDALSLT
RCQQEESQAARMIYSTAGLYNHFIKGLDSFSGKPRGSGAPAGTALPLEGV
ILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCI
DRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALFS
NNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLD
KHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYV
TSIRPNIFVGRAEGTTQYSKWYFEVMVDEVVPFLTAQATHLRVGWALTEG
YSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVPRLVTSPGQHLLAPE
DVVSCCLDLSVPSISFRINGCPVQGVFEAFNLNGLFFPVVSFSAGVKVRF
LLGGRHGEFKFLPPPGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVG
PSRCLSHTDFVPCPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLR
KTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRV
AQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGY
NIRVRIFRAEKSYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGAD
ELAYVFNGHRGQRWHLGSELFGRPWQSGDVVGCMIDLTENTIIFTLNGEV
LMSDSGSETAFRDIEVGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICG
LQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVSRVDGTVDTPP
CLRLTHRSLVEMLFLRLSLPVQFHQLNTTTYYYSVRVFAGQEPSCVWVGW
VTPDYHQHDMNFDLTKVRAVTVTMGDSLKCSNCYMVWGGDFVDLVIGCLV
DLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQK
NIMPLSAAMFLSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLRVETRRA
GERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQQFHSHTLRLY
RAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHL
ESACRSRRSMLSEYIVPLTPETRAITLFPPRHGLPGVGVTTSLRPPHHFS
APCFVAALPEAPARLSPSIPLEALRDKALRMLGEAVRDGGQHARDPVGGS
VEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVEGLLQMKLPESVK
LQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGILMKAFTM
TAAETARRTREFRSPPQEQINMLLHFKPLPDEIRQDLLEFHQDLLTHCGI
QLQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALP
RAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNK
VFYQHPNLMRALGMHETVMEVMVNVLGRFPKMVTSCCRFLCYFCRISRQN
QRSMFDHLSYLLENSGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLA
GCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVV
VRLLIRKPECFGPALLLATIEEGHAIMSFYAALIDLLGRCAPEMHLIQAG
KGEALRIRAILRSLVPLDDLVGIISLPKMSASFVPDHKASMVLFLDRVYG
FLLHVLDVGFLPDMRAAALALNRYLCLAVLPLITKCAPLFAMVDSMLHTV
YRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAADPRPVETLN
VIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPY
KTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEYNPQPPDLSGVTLS
RELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKAR
DREKAQELLKFLQMNGYAVTRAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPLLIRYVDNN
RAHWLTEPNPSAEELFRMVGEIFIYWSKAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAASLRWQMALYRGAAAAAAAAAAAAAAAAAAAAAMTP
LYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEV
EEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLSFEEK
EMEKQRLLYQQARLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILN
GGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGE
KVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDY
LLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGP
CTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKD
MVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIV
GSEAFQDYVTDPRGLISKKDFQKAAAAAAEEFANRFQEPARDIGFNVAVL
LTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFE
ISETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQ
IAAQEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPVYY
FLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARK
LEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGD
IYGRERIAEIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAA
HLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRK
FYNKDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDI
TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDYF
DTTPHRFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERC
WDFFPAGDCFRKQYEDQLS

3D structure

• PDB: 6w1n Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
• Chain: H
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	H	C4956 H4976 H4981	C3640 H3660 H3665

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 19:26:30 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6w1n', asym_id = 'H', title = 'Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6w1n', asym_id='H', title='Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6w1n', asym_id = 'H'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6w1n', asym_id='H')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>