Structure of PDB 6v4x Chain H

Receptor sequence

>6v4xH (length=499) Species: 9606 (Homo sapiens) [Search protein sequence]

SDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDL
IDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLS
DYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGH
VLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYG
THIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQ
NHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHI
SNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYC
VEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRA
LKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNF
RGEKLAKVMGFLADGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVK

3D structure

PDB

6v4x Structure of an active human histone pre-mRNA 3'-end processing machinery.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.27.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	H	V23 P45 H73 L74 D75 D109 Y110 K112 V113 N115 H158 T206 Y207 S272 S273 K312 H316 S328 P329 S334 E339 Y357 H396 H418 E420	V15 P37 H65 L66 D67 D101 Y102 K104 V105 N107 H150 T198 Y199 S264 S265 K304 H308 S320 P321 S326 E331 Y349 H388 H410 E412
BS02	ZN	H	H71 H73 H158 D179	H63 H65 H150 D171
BS03	ZN	H	D75 H76 D179 H418	D67 H68 D171 H410

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004521	RNA endonuclease activity
GO:0004534	5'-3' RNA exonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage
GO:0031124	mRNA 3'-end processing
GO:0180010	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6v4x, PDBe:6v4x, PDBj:6v4x
PDBsum	6v4x
PubMed	32029631
UniProt	Q9UKF6\|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (Gene Name=CPSF3)

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