Structure of PDB 6usa Chain H

Receptor sequence
>6usaH (length=403) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
IAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQDF
LDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINN
VLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTA
RQALNVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGT
AAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIGI
FHAFLDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQDE
DGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLC
RMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKWF
GLL
3D structure
PDB6usa Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.
ChainH
Resolution2.406 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K101 E123 S390
Catalytic site (residue number reindexed from 1) K97 E119 S386
Enzyme Commision number 4.2.1.20: tryptophan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PZJ H F188 W191 Y200 F202 G207 P208 H294 G295 F184 W187 Y196 F198 G203 P204 H290 G291
BS02 P1T H H100 K101 T124 G125 A126 Q128 H129 T204 G246 G248 S249 N250 G317 E364 S390 H96 K97 T120 G121 A122 Q124 H125 T200 G242 G244 S245 N246 G313 E360 S386
Gene Ontology
Molecular Function
GO:0004834 tryptophan synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
GO:1901605 alpha-amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usa, PDBe:6usa, PDBj:6usa
PDBsum6usa
PubMed31930594
UniProtP9WFX9|TRPB_MYCTU Tryptophan synthase beta chain (Gene Name=trpB)

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