Structure of PDB 6tbb Chain H

Receptor sequence
>6tbbH (length=259) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
HMASLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKE
LEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFA
NMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTY
LGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLS
AKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIH
VDSGFHAIK
3D structure
PDB6tbb The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
ChainH
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.39: enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP H G13 I14 A15 S19 I20 R40 S44 D66 V67 S93 I94 A95 I120 T145 T146 K164 A190 P192 I193 T195 S197 G16 I17 A18 S22 I23 R43 S47 D69 V70 S96 I97 A98 I123 T148 T149 K167 A193 P195 I196 T198 S200
BS02 KAL H F96 A97 Y157 S197 V201 F204 F99 A100 Y160 S200 V204 F207
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050661 NADP binding
GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6tbb, PDBe:6tbb, PDBj:6tbb
PDBsum6tbb
PubMed32208550
UniProtQ6GI75|FABI_STAAR Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Gene Name=fabI)

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