Structure of PDB 6t56 Chain H

Receptor sequence
>6t56H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB6t56 Thrombin in Complex with Benzylamine
ChainH
Resolution1.31 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 Q38 L65 R73 T74 R75 Y76 K81 I82 F19 Q24 L60 R68 T69 R70 Y71 K77 I78
BS02 ABN H A190 C191 E192 V213 W215 G216 G219 A193 C194 E195 V218 W220 G221 G223
BS03 ABN H E97A N98 L99 W215 E94 N95 L96 W220
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6t56, PDBe:6t56, PDBj:6t56
PDBsum6t56
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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