Structure of PDB 6t53 Chain H

Receptor sequence

>6t53H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G

3D structure

PDB

6t53 Thrombin in Complex with a D-Phe-Pro-p-benzylamine derivative

Chain

Resolution

1.35 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)	H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number	3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	H	E23 G25 M26 P28 W29 F114 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207	E8 G10 M11 P13 W14 F111 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 P207 N210 R211 W212
BS02	peptide	H	F34 L40 L65 R67 R73 T74 R75 Y76 K81 I82	F19 L26 L60 R62 R68 T69 R70 Y71 K77 I78
BS03	K73	H	Y60A W60D N98 D189 A190 E192 W215 G216 G219	Y47 W50 N95 D192 A193 E195 W220 G221 G223

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6t53, PDBe:6t53, PDBj:6t53
PDBsum	6t53
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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