Structure of PDB 6t3m Chain H

Receptor sequence
>6t3mH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
3D structure
PDB6t3m Thrombin in Complex with a D-Phe-Pro-p-phenol derivative
ChainH
Resolution1.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H L40 L65 R73 T74 R75 Y76 K81 I82 L26 L60 R68 T69 R70 Y71 K77 I78
BS02 MD8 H Y60A N98 I174 V213 S214 W215 G216 Y47 N95 I172 V218 S219 W220 G221
BS03 MD8 H I47 L123 P124 K235 I238 I33 L120 P121 K240 I243
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6t3m, PDBe:6t3m, PDBj:6t3m
PDBsum6t3m
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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