Structure of PDB 6r2w Chain H

Receptor sequence
>6r2wH (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRVMTQDCEASYPGKITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWY
LTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB6r2w Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
ChainH
Resolution1.25 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H56 D105 K199 G200 D201 S202
Catalytic site (residue number reindexed from 1) H41 D90 K184 G185 D186 S187
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E73 D75 E78 E83 E58 D60 E63 E68
BS02 0Z7 H H56 G100 T101 T102 D196 S197 C198 K199 G200 S202 S221 W222 G223 G225 H41 G85 T86 T87 D181 S182 C183 K184 G185 S187 S206 W207 G208 G210
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6r2w, PDBe:6r2w, PDBj:6r2w
PDBsum6r2w
PubMed31801825
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

[Back to BioLiP]