Structure of PDB 6pyc Chain H

Receptor sequence

>6pycH (length=204) Species: 10090 (Mus musculus) [Search protein sequence]

IVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWFQQKPGQPPK
LLIYWASLRESGVSDRFSGSGSGTDFTLTISGLQAEDVAVYYCQQYYSIL
WTFGQGTKVEIKSTKGPSVFPLAPCTAALGCLVKDYFPEPVTVSWNSGAL
TSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDK
RVES

3D structure

PDB

6pyc Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.

Chain

Resolution

3.6 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	P4S	H	Y97 I100	Y96 I99	PDBbind-CN: -logKd/Ki=7.45,Kd=35.8nM
BS02	P4S	H	Q95 W102	Q94 W101	PDBbind-CN: -logKd/Ki=7.45,Kd=35.8nM

External links

PDB	RCSB:6pyc, PDBe:6pyc, PDBj:6pyc
PDBsum	6pyc
PubMed	31879340

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