Structure of PDB 6om7 Chain H

Receptor sequence

>6om7H (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMAR
MARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFV
KLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNA
LIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKK
TTHFVEGGDAGNREDQINRLIRRMN

3D structure

PDB

6om7 Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.7 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	R134 K222 T225 H226	R111 K199 T202 H203
BS02	rna	H	N24 F25 K31 R32 L33 K35 Q39 R43 R47 K48 Y51 E52 H58 Y61 R62 Q63 Y65 R66 R70 R73 M74 R76 K77 R96 G97 I98 N99 P103 K107 L111 R113 I117 A128 N131 M132 N146 L147 K148 N151 K156 R157 K165 R166 Y182 E188 K202 N206 K212 L213 S214 S215 P216 R217 G219 M220 K222 K223 R242 R245	N1 F2 K8 R9 L10 K12 Q16 R20 R24 K25 Y28 E29 H35 Y38 R39 Q40 Y42 R43 R47 R50 M51 R53 K54 R73 G74 I75 N76 P80 K84 L88 R90 I94 A105 N108 M109 N123 L124 K125 N128 K133 R134 K142 R143 Y159 E165 K179 N183 K189 L190 S191 S192 P193 R194 G196 M197 K199 K200 R219 R222

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0042802	identical protein binding

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6om7, PDBe:6om7, PDBj:6om7
PDBsum	6om7
PubMed	31160784
UniProt	P18124\|RL7_HUMAN Large ribosomal subunit protein uL30 (Gene Name=RPL7)

[Back to BioLiP]