Structure of PDB 6olf Chain H

Receptor sequence

>6olfH (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMAR
MARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFV
KLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNA
LIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKK
TTHFVEGGDAGNREDQINRLIRRMN

3D structure

PDB

6olf Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	R134 E137 K222 H226	R111 E114 K199 H203
BS02	rna	H	N24 F25 A26 K29 K31 R32 L33 R34 K35 K36 F37 R43 R47 K48 Y51 H58 Y61 R62 Y65 R66 R70 R73 M74 R76 G97 I98 N99 G100 P103 K104 K107 L111 R113 Q116 I117 K127 A128 N131 M132 N146 L147 K148 N151 K165 R166 E188 R200 K202 N206 K212 S214 S215 P216 R217 M220 K222 K223 R242 R245	N1 F2 A3 K6 K8 R9 L10 R11 K12 K13 F14 R20 R24 K25 Y28 H35 Y38 R39 Y42 R43 R47 R50 M51 R53 G74 I75 N76 G77 P80 K81 K84 L88 R90 Q93 I94 K104 A105 N108 M109 N123 L124 K125 N128 K142 R143 E165 R177 K179 N183 K189 S191 S192 P193 R194 M197 K199 K200 R219 R222

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0042802	identical protein binding

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6olf, PDBe:6olf, PDBj:6olf
PDBsum	6olf
PubMed	31160784
UniProt	P18124\|RL7_HUMAN Large ribosomal subunit protein uL30 (Gene Name=RPL7)

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