Structure of PDB 6ole Chain H

Receptor sequence

>6oleH (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMAR
MARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFV
KLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNA
LIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKK
TTHFVEGGDAGNREDQINRLIRRMN

3D structure

PDB

6ole Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	R134 K222 T225 H226 E229	R111 K199 T202 H203 E206
BS02	rna	H	N24 F25 A26 E27 K29 K31 R32 L33 K35 K36 R47 K48 Y51 E52 H58 Y61 R62 Y65 R66 R70 R73 M74 R76 A78 R96 G97 I98 N99 G100 P103 K104 K107 L111 R113 Q116 I117 A128 N131 M132 N146 L147 K148 N151 K165 R166 E188 K202 K212 L213 S215 P216 R217 G219 M220 K222 K223 R242 R245	N1 F2 A3 E4 K6 K8 R9 L10 K12 K13 R24 K25 Y28 E29 H35 Y38 R39 Y42 R43 R47 R50 M51 R53 A55 R73 G74 I75 N76 G77 P80 K81 K84 L88 R90 Q93 I94 A105 N108 M109 N123 L124 K125 N128 K142 R143 E165 K179 K189 L190 S192 P193 R194 G196 M197 K199 K200 R219 R222

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0042802	identical protein binding

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6ole, PDBe:6ole, PDBj:6ole
PDBsum	6ole
PubMed	31160784
UniProt	P18124\|RL7_HUMAN Large ribosomal subunit protein uL30 (Gene Name=RPL7)

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