Structure of PDB 6mwn Chain H

Receptor sequence

>6mwnH (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

EVQLVESGGGLVQPGGSLRLSCAASGFSLSSSSMHWVRQAPGKGLEWVAS
ISPYSGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARTK
YHYKNYYWWALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALG
CLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKKVEPK

3D structure

PDB

6mwn A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.

Chain

Resolution

2.838 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	H	S33 S55 Y57 S58 Y104 H105 Y106 K107 N108 Y109 Y110 W111 W112	S30 S52 Y54 S55 Y101 H102 Y103 K104 N105 Y106 Y107 W108 W109	PDBbind-CN: Kd=44nM
BS02	rna	H	E4 L173 S175 S201 T205 Q206	E1 L170 S172 S198 T202 Q203	PDBbind-CN: Kd=44nM

External links

PDB	RCSB:6mwn, PDBe:6mwn, PDBj:6mwn
PDBsum	6mwn
PubMed	31399592

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