Structure of PDB 6mv4 Chain H

Receptor sequence
>6mv4H (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
3D structure
PDB6mv4 Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study.
ChainH
Resolution1.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D89 Q182 G183 D184 S185 G186
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 H K132 R165 K121 R153
BS02 SO4 H N129A K132 N117 K121
BS03 SO4 H N178 R233 N166 R223
BS04 PBZ H D189 S190 C191 Q192 S195 W215 G216 C220 D179 S180 C181 Q182 S185 W205 G206 C209
BS05 CA H E70 N72 E75 E77 E80 E55 N57 E60 E62 E65
BS06 NA H F184A H185 G187 A221 M221A K222 K224 F173 H174 G176 A210 M211 K212 K214
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6mv4, PDBe:6mv4, PDBj:6mv4
PDBsum6mv4
PubMed30725510
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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