Structure of PDB 6mev Chain H

Receptor sequence
>6mevH (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERAD
ALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFK
CGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDY
KVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALV
QGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPP
EFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHK
TVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIAS
3D structure
PDB6mev JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes.
ChainH
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AKG H Y131 T184 H187 N197 H273 V275 T285 Y131 T184 H187 N197 H273 V275 T285
BS02 FE H H187 D189 H273 H187 D189 H273
BS03 NMM H F133 W174 G185 H187 F133 W174 G185 H187
External links
PDB RCSB:6mev, PDBe:6mev, PDBj:6mev
PDBsum6mev
PubMed32048991
UniProtQ6NYC1|JMJD6_HUMAN Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Gene Name=JMJD6)

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