Structure of PDB 6k0r Chain H

Receptor sequence
>6k0rH (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
EVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVE
LIKSKKMAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYST
EIKKTEVLMENFRRAIGLRIIQDVTLHDLDVANARTEITDKLRGEINKVV
NKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNR
GNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEG
INISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEI
SELFYDAKSSAKILADQQ
3D structure
PDB6k0r Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals.
ChainH
Resolution2.502 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CUU H S17 H18 H20 L39 V40 G73 G75 K76 T77 Y366 I374 S13 H14 H16 L35 V36 G69 G71 K72 T73 Y233 I241
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6k0r, PDBe:6k0r, PDBj:6k0r
PDBsum6k0r
PubMed32376767
UniProtQ9Y265|RUVB1_HUMAN RuvB-like 1 (Gene Name=RUVBL1)

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