Structure of PDB 6jgz Chain H

Receptor sequence

>6jgzH (length=3485) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD
LSICTFVLEQSLSVRALQEMLANTFMMKTAQGGGHRTLLYGHAILLRHSY
SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKV
RVGDDLILVSVSSERYLHLSYLHVDAAFQQTLWSVAPISSGSEAAQGYLI
GGDVLRLLHGECLTVPSGEHEQRRTVHYEGGAVSVHARSLWRLETLRVAW
SGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSS
KEKRKEVDGMGTSEIKYGDSVCFIQHIGTGLWLTYQSSIQRKAIMHHEGH
MDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLP
IESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLV
LECIDRLHVYSSVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGS
LDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKH
GRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSS
MRPNIFLGKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEE
WGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLS
APSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGEFKFLPP
PGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSAFTPIPVDTS
QIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVE
FSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAYQLTSGYKPAPMD
LSFIKLTPSQEAMVDKLAENAHNVWARDRIRQRRNPRLVPYALLDDRTKK
SNKDSLREAVRTLLGYGYNLEARFRIFRAEKTYAVKAGRWYFEFEAVTAG
DMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDV
VGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQ
VGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV
PSSHEHIEVTRIDVTQKSFGSQNSSTDIMFYRLSMPIECTYYYSVRIFPN
VWVGWITSDFHQYDTAFDLVTVTLGDEKGKVHESIKRSNYMVCANNNGLE
IGCVVGLLTFTANGKDLSTYYQVEPSTKLFPAVFAQATSPNVFQFEAGLF
KSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQC
LEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHR
VAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMM
NNEFIVPMTEETKSITLFPDGLPGIGLSTSLRPRMQFSSPSFVSINNECY
QYSPEFPLDILKAKTIQMLTEAVQEGSLHARDPVGGTTEFLFVPLIKLFY
TLLIMGIFHNEDLKHILQLIEPSGLLQMKLPEPVKLQMCLLLQYLCDCQV
RHRIEAIVAFSDDFVAKLQDNQRFRYNEVRDQLLDFHEDLMTHCGIELDS
DLTIRGRLLSLVEKVTYLTLQQLISETMVRWAQESVIEDPELVRAMFVLL
HRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEE
EKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGFPKMVANC
CRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAAS
VMDNNELALALREPDLEKVVRYLAGCGPVEGERYLDFLRFAVFCNGESVE
ENANVVVRLLIRRPEGLLAAMEEAIKIGNAIMTFYAALIDLLGRCAEAIR
IRSILRSGDLVGVISIAFQFCPDHKAAMVLFLDRVYVQDFLLHLLGFLPD
LRAAASLTDMALALNRYLCTAVLPLLPLFAGTEHHASLIDSLLHTVKGCS
LTKAQRDSIEVCLLSRPSMMQHLLRRLVFDVPLLNKMPLKLLTNHYERCW
KYYCLPGGASEEELHLSRKLFWGIFDALYEQELFKLALPCLSAVAGALPP
NFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSD
SSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDDAA
HGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNH
PLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGYFLSAASRPLCS
GGHASNKEKEMVFCKLGVLVRHRISLFGNDATLHILGQTLDARTVMKTGL
ESVKFLDNAAEDLEKTMENLKQGQFTTTVALLPMLSSLFEHIGQHQFLED
VQVSCYRILTSLYALGTSVERQRSALGECLAAFAGAAFLETHLDKHNIYS
YNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPRVDPLHQLILL
FSRTALTEKCKLEEDFLYMAYADIMAKSCSFEEKEMEKQKLLYQQARLHD
RGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLEYLKE
KKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGKVLQDDEFTCDLFRFLQ
LLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSG
KDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAV
VGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGT
IGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVIS
KRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDI
GFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKR
IERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCE
DTIFEMQLAAQIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKV
SVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKE
VARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMD
KYGEFYGRDRISELLGSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTM
SVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV
YLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIG
DEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQE
QVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINK
DETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYE

3D structure

• PDB: 6jgz Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
• Chain: H
• Resolution: 4.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	H	I4891 C4892 H4914	I3412 C3413 H3435

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Tue Nov 26 07:00:49 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6jgz', asym_id = 'H', title = 'Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6jgz', asym_id='H', title='Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6jgz', asym_id = 'H'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6jgz', asym_id='H')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>