Structure of PDB 6fvx Chain H

Receptor sequence
>6fvxH (length=426) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
AAPYAAKLKQTENDLKDIEARIKEKAGVKESDTGLAPSHLWDIMGDRQRL
GEEHPLQVARCTKIIKGNGESDETTTDNNNSGNSNSNSNQQSTDADEDDE
DAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSKYNIELPLPPRI
DPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGID
PPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMV
RELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLD
GFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRI
HSKSMSVERGIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEK
DFLKAVDKVISGYKKFSSTSRYMQYN
3D structure
PDB6fvx Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.
ChainH
Resolution4.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP H G212 P252 G253 T254 G255 K256 T257 L258 R261 E310 I388 G416 A417 G171 P211 G212 T213 G214 K215 T216 L217 R220 E269 I347 G375 A376
BS02 ATP H D341 R367 D300 R326
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031625 ubiquitin protein ligase binding
GO:0036402 proteasome-activating activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6fvx, PDBe:6fvx, PDBj:6fvx
PDBsum6fvx
PubMed30067984
UniProtP33299|PRS7_YEAST 26S proteasome regulatory subunit 7 homolog (Gene Name=RPT1)

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